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EP 4 823 612 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904722.6 (22) Date of filing: 10.12.2024

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) C07K 16/18(2006.01) C07K 16/44(2006.01) C12N 15/864(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/44; C12N 15/86; C12N 2750/14143; A61K 48/005; A01K 2227/105; A01K 2217/052; A01K 2267/0318; A61P 21/00; A61K 2039/505; C07K 2317/76; C07K 2317/622 (86) International application number: PCT/US2024/059352 (87) International publication number: WO 2025/128551 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608667 P 16.02.2024 US 202463554852 P 10.05.2024 US 202463645222 P (71) Applicants: University of Florida Research Foundation, Incorporated Gainesville, FL 32611 (US) The Children's Hospital Of Philadelphia Philadelphia, PA 19104 (US)

(72) Inventors: ROMANO, Lisa Gainesville, FL 32611 (US) DAVIDSON, Beverly, L. Philadelphia, PA 19104 (US) RANUM, Laura Gainesville, FL 32611 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)