(19)
(11) EP 4 823 617 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24904670.7

(22) Date of filing: 06.12.2024
(51) International Patent Classification (IPC): 
A61K 40/31(2025.01)
A61K 40/15(2025.01)
C12N 15/62(2006.01)
A61P 35/00(2006.01)
 A61K 40/11(2025.01)
C07K 14/705(2006.01)
C12N 15/86(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 40/11; A61K 40/31; A61P 35/00; C12N 15/86; C12N 2740/16043; C07K 14/70535; C07K 14/7051; C07K 14/70517; C07K 14/70521; C07K 2319/00; C07K 14/70578; A61K 40/4202; A61K 40/4224
(86) International application number:
PCT/US2024/058938
(87) International publication number:
WO 2025/128434 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 14.12.2023 US 202363610215 P

(71) Applicant: The Regents of the University of Colorado, a body corporate
Denver, CO 80203 (US)

(72) Inventors:
  • KOHLER, Mark Eric
    Denver, Colorado 80203 (US)
  • SIMPSON, Haley
    Denver, Colorado 80203 (US)
  • DANIS, Catherine
    Denver, Colorado 80203 (US)
  • LEACH, Lillie
    Denver, Colorado 80203 (US)
  • NOVAK, Amanda
    Denver, Colorado 80203 (US)

(74) Representative: Fish & Richardson P.C. 
Highlight Business Towers Mies-van-der-Rohe-Straße 8
80807 München
80807 München (DE)

   


(54) COMPOSITIONS AND METHODS FOR THE TREATMENT OF VEN/AZA RESISTANT ACUTE MYELOID LEUKEMIA