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EP 4 823 618 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24827817.8 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  A61K 41/00(2020.01) A61K 9/06(2006.01) A61P 35/00(2006.01) A61K 9/00(2006.01) A61K 9/51(2006.01) (52) Cooperative Patent Classification (CPC): A61K 41/0057; A61K 9/5115; A61P 35/00; A61K 9/06; A61K 9/0019 (86) International application number: PCT/EP2024/085805 (87) International publication number: WO 2025/125384 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 EP 23215681 (71) Applicants: Cambridge Enterprise Limited Cambridge, Cambridgeshire CB2 1TN (GB) UNIVERSIDADE NOVA DE LISBOA 1099-085 Lisboa (PT)

(72) Inventors: FAIREN-JIMENEZ, David Cambridge, Cambridgeshire CB2 1TN (GB) CHEN, Xu Cambridge, Cambridgeshire CB2 1TN (GB) DIOGO OSÓRIO DE CASTRO CONDE, João Cambridge, Cambridgeshire CB2 1TN (GB) BRUNA DA SILVA MENDES, Bárbara Cambridge, Cambridgeshire CB2 1TN (GB) MIGUEL DE OLIVEIRA CONNIOT, João Cambridge, Cambridgeshire CB2 1TN (GB) (74) Representative: Patent Boutique LLP  10A Printing House Yard Hackney Road London E2 7PR London E2 7PR (GB)