(19)

(11)

EP 4 823 622 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24834168.7 (22) Date of filing: 09.12.2024

(51) International Patent Classification (IPC):  A61K 47/54(2017.01) C07D 409/00(2006.01) A61P 11/00(2006.01) C12N 15/113(2010.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; A61K 47/545; A61P 11/00; C07D 471/04; C07D 519/00; C12N 15/111; C12N 2310/14; C12N 2310/351   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/322, C12N 2310/3533; C12N 2310/315, C12N 2310/344; C12N 2310/312, C12N 2310/344; (86) International application number: PCT/US2024/059138 (87) International publication number: WO 2025/128462 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 12.12.2023 US 202363608962 P (71) Applicant: Eli Lilly and Company Indianapolis, IN 46285 (US)

(72) Inventors: FRIMPONG, Kwame Indianapolis, Indiana 46206-6288 (US) GANGRAS, Pooja Indianapolis, Indiana 46206-6288 (US) GAVARDINAS, Konstantinos Indianapolis, Indiana 46206-6288 (US) WILLIAMSON, Colton James Indianapolis, Indiana 46206-6288 (US) (74) Representative: Eli Lilly and Company Limited  8 Arlington Square West Downshire Way Bracknell, Berkshire RG12 1PU Bracknell, Berkshire RG12 1PU (GB)