(19)

(11)

EP 4 823 623 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904937.0 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  A61K 47/60(2017.01) A61K 45/06(2006.01) A61K 9/127(2025.01) A61P 37/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 37/00; A61K 45/06; A61K 47/60; A61K 47/10; A61K 9/0019; A61K 9/1271 (86) International application number: PCT/US2024/059956 (87) International publication number: WO 2025/128945 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610090 P (71) Applicant: The University of North Carolina at Chapel Hill Chapel Hill, NC 27514 (US)	(72) Inventors: LAI, Samuel Chapel Hill, North Carolina 27514 (US) LI, Zhongbo Chapel Hill, North Carolina 27514 (US) SHEN, Limei Chapel Hill, North Carolina 27514 (US) (74) Representative: Guardian IP Consulting I/S  Diplomvej, Building 381 2800 Kgs. Lyngby 2800 Kgs. Lyngby (DK)