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(11)

EP 4 823 625 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24837544.6 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C07D 491/22(2006.01) A61P 35/00(2006.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/68037; A61K 47/6851; C07K 16/2827; A61P 35/00; C07D 491/22; A61K 47/6849; A61K 47/6889; A61K 2039/505; C07K 2317/73 (86) International application number: PCT/CN2024/138655 (87) International publication number: WO 2025/124456 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 WO PCT/CN2023/138423 (71) Applicant: BeOne Medicines I GmbH 4051 Basel (CH)	(72) Inventors: TSAI, Charng-Sheng Beijing 102206 (CN) TSAI, Mei-Hsuan Shanghai 200131 (CN) WANG, Zewei Shanghai 200131 (CN) LUO, Wei Shanghai 200131 (CN) HE, Maomao Shanghai 200131 (CN) LI, Bing Shanghai 200131 (CN) WEI, Xiaodong Shanghai 200131 (CN) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)