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EP 4 823 626 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904880.2 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C07K 16/28(2006.01) A61K 39/395(2006.01) A61K 31/4745(2006.01) A61K 47/65(2017.01) A61P 35/00(2006.01) C07D 491/22(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/395; A61P 35/00; C07D 491/22; C07K 16/28; C07K 2317/24; C07K 2317/90; C07K 2317/92; C07K 2317/94; A61K 47/68037; A61K 47/6889; A61K 47/6851; A61K 47/6849 (86) International application number: PCT/US2024/059794 (87) International publication number: WO 2025/128837 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 CN 202311712634 (71) Applicant: SystImmune, Inc. Redmond WA 98052 (US)	(72) Inventors: ZHU, Yi Redmond, Washington 98052 (US) ZHUO, Shi Chengdu, Sichuan 611130 (CN) WAN, Weili Chengdu, Sichuan 611130 (CN) ZHANG, Yong Chengdu, Sichuan 611130 (CN) LI, Gangrui Chengdu, Sichuan 611130 (CN) (74) Representative: Mathys & Squire  32 London Bridge Street The Shard London SE1 9SG London SE1 9SG (GB)