(19)

(11)

EP 4 823 629 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904726.7 (22) Date of filing: 10.12.2024

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61P 27/16(2006.01) A61B 5/12(2006.01) C07K 14/47(2006.01) A61F 11/20(2022.01) (52) Cooperative Patent Classification (CPC): A61B 5/12; C07K 14/47; A61P 27/16; C12N 15/86; C12N 2800/40; C12N 2750/14143; C12N 2830/42; A61K 48/005; A61K 48/0066; A61F 11/00 (86) International application number: PCT/US2024/059365 (87) International publication number: WO 2025/128559 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608803 P 02.02.2024 US 202463549424 P (71) Applicant: Akouos, Inc. Boston, MA 02210 (US)	(72) Inventors: WELLMAN, Jennifer Boston, MA 02210 (US) SIMONS, Emmanuel John Boston, MA 02210 (US) VALERO, Michelle Boston, MA 02210 (US) SEWELL, William Boston, MA 02210 (US) HICKOX, Ann Boston, MA 02210 (US) NG, Robert Boston, MA 02210 (US) (74) Representative: Eli Lilly and Company Limited  8 Arlington Square West Downshire Way Bracknell, Berkshire RG12 1PU Bracknell, Berkshire RG12 1PU (GB)