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(11)

EP 4 823 630 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904783.8 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C12N 15/12(2006.01) A61P 25/28(2006.01) C12N 15/86(2006.01) C12N 15/63(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/28; C12N 15/63; C12N 15/86; C12N 2750/14143; A01K 2217/075; A01K 2217/052; A01K 2217/15; A01K 2227/105; A01K 2267/0312; A61K 48/005; A61K 48/0058; C07K 2319/00; C07K 14/4702; C07K 14/4711; C07K 14/81; C07K 14/485 (86) International application number: PCT/US2024/059509 (87) International publication number: WO 2025/128661 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 12.12.2023 US 202363609136 P (71) Applicant: Baylor College of Medicine Houston, TX 77030 (US)	(72) Inventors: DENEEN, Benjamin Houston, Texas 77030 (US) KWON, Ukbong Houston, Texas 77030 (US) WOO, Junsung Houston, Texas 77030 (US) CHOI, Dongjoo Houston, Texas 77030 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)