(19)

(11)

EP 4 823 637 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24837760.8 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  A61K 51/10(2006.01) C07K 16/28(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 51/1045; C07K 16/28; A61P 35/00; C07K 2317/92; C07K 2317/94; A61K 2039/505; C07K 2317/55 (86) International application number: PCT/US2024/059745 (87) International publication number: WO 2025/128807 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609667 P (71) Applicant: Amgen Inc. Thousand Oaks, California 91320-1799 (US)	(72) Inventors: WU, Bin Thousand Oaks, California 91320-1799 (US) LI, Cong Thousand Oaks, California 91320-1799 (US) STALEY, Binnaz Thousand Oaks, California 91320-1799 (US) ILOVICH, Ohad Thousand Oaks, California 91320-1799 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)