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EP 4 823 676 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24829433.2 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  A61P 11/00(2006.01) A61P 35/00(2006.01) C07D 401/14(2006.01) C07D 471/04(2006.01) C07D 519/00(2006.01) A61K 31/5025(2006.01) A61K 31/4545(2006.01) A61P 29/00(2006.01) A61P 37/00(2006.01) C07D 413/14(2006.01) C07D 487/04(2006.01) A61K 31/513(2006.01) A61K 31/496(2006.01) (52) Cooperative Patent Classification (CPC): A61P 11/00; A61P 29/00; A61P 35/00; A61P 37/00; C07D 401/14; C07D 413/14; C07D 471/04; C07D 487/04; C07D 519/00 (86) International application number: PCT/EP2024/086233 (87) International publication number: WO 2025/125575 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610021 P 02.04.2024 LB 1303624 03.04.2024 US 202418625479 05.04.2024 WO PCT/EP2024/059317 03.10.2024 EP 24204519 (71) Applicant: Astrazeneca AB 151 85 Södertälje (SE)

(72) Inventors: TERSTIEGE, Ina 151 85 Södertälje (SE) PERRY, Matthew 151 85 Södertälje (SE) GARRISON, Aaron Thomas 151 85 Södertälje (SE) JOHANSSON, Johan 151 85 Södertälje (SE) KWAPIE , Karolina 151 85 Södertälje (SE) (74) Representative: AstraZeneca Intellectual Property  Eastbrook House Shaftesbury Road Cambridge CB2 8BF Cambridge CB2 8BF (GB)