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(11)

EP 4 823 686 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24841572.1 (22) Date of filing: 16.12.2024

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07K 16/28(2006.01) A61K 40/42(2025.01) (52) Cooperative Patent Classification (CPC): A61K 40/4211; C07K 16/2803; C07K 16/2815; A61P 35/00; C07K 2317/622; C07K 2317/33; C07K 2317/522; C07K 2317/524; C07K 2317/53; C07K 2317/565; C07K 2317/40; C07K 2317/34; C07K 2317/92; C07K 2317/94; C07K 2317/24; C07K 2317/35; A61K 2039/505; C07K 2317/54; C07K 2317/55; C07K 2317/71; A61K 40/31; A61K 40/11; A61K 40/4215; A61K 40/4221 (86) International application number: PCT/US2024/060426 (87) International publication number: WO 2025/129201 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363610917 P 31.05.2024 US 202463654930 P 17.10.2024 US 202463708461 P (71) Applicant: Capstan Therapeutics, Inc. North Chicago, IL 60064 (US)

(72) Inventors: NGUYEN, Duy Chicago, IL 60064 (US) PRESTA, Leonard, G. San Francisco, CA 94109 (US) MARTINKO, Alexander San Francisco, CA 94122 (US) YONG, Qian-Chen Chicago, IL 60064 (US) SIEVERS, Stuart, Aaron Van Nuys, CA 91406 (US) (74) Representative: Mathys & Squire  32 London Bridge Street The Shard London SE1 9SG London SE1 9SG (GB)