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EP 4 823 724 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24828678.3 (22) Date of filing: 10.12.2024

(51) International Patent Classification (IPC):  B01D 71/02(2006.01) C12M 1/42(2006.01) C12M 1/34(2006.01) C12N 15/87(2006.01) B01D 67/00(2006.01) C12M 3/06(2006.01) C12N 5/00(2006.01) (52) Cooperative Patent Classification (CPC): B01D 71/0213; B01D 71/0215; B01D 71/027; B01D 67/0062; C12M 35/04; C12M 41/40; C12N 15/87 (86) International application number: PCT/US2024/059370 (87) International publication number: WO 2025/128563 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608754 P (71) Applicant: Portal Biotechnologies, Inc. Arlington, MA 02476 (US)

(72) Inventors: BARCLAY, Alec John Arlington, Massachusetts 02476 (US) SHAREI, Armon Reza Arlington, Massachusetts 02476 (US) SIKORA HANSON, Jacquelyn Lee Arlington, Massachusetts 02476 (US) DUARTE RIVEROS, Pedro Alejandro Edmonton, Alberta T6W 2N7 (CA) FINOT, Michael Edmonton, Alberta T6W 2N7 (CA) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)