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EP 4 823 728 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24837778.0 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  B01F 35/22(2022.01) G01N 21/90(2006.01) G06F 30/28(2020.01) G06F 113/08(2020.01) (52) Cooperative Patent Classification (CPC): G01N 21/9009; G01N 21/9027 (86) International application number: PCT/US2024/059929 (87) International publication number: WO 2025/128925 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363611058 P (71) Applicant: AMGEN, INC. Thousand Oaks, CA 91320-1799 (US)	(72) Inventors: MILNE, Graham, F. Thousand Oaks, CA 91320-1799 (US) ASADI, Hossein Thousand Oaks, CA 91320-1799 (US) PEARSON, Thomas, Clark Thousand Oaks, CA 91320-1799 (US) BERNACKI, Joseph, Peter Thousand Oaks, CA 91320-1799 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)