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EP 4 823 755 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24837744.2 (22) Date of filing: 10.12.2024

(51) International Patent Classification (IPC):  B01L 3/00(2006.01) C12M 1/00(2006.01) C12M 1/42(2006.01) B01D 63/08(2006.01) C12M 1/26(2006.01) (52) Cooperative Patent Classification (CPC): C12M 33/04; C12M 35/00; C12M 35/04; C12M 29/04; B01D 63/087; B01D 2313/18; B01D 2313/12; B01D 2313/90; B01L 3/5635; C12M 23/16; B01L 2300/0681 (86) International application number: PCT/US2024/059380 (87) International publication number: WO 2025/128572 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608757 P (71) Applicant: Portal Biotechnologies, Inc. Arlington, MA 02476 (US)

(72) Inventors: SHAREI, Armon Reza Arlington, Massachusetts 02476 (US) BARCLAY, Alec John Arlington, Massachusetts 02476 (US) HIRSCH, Sophia Madeleine Arlington, Massachusetts 02476 (US) SONG, Zhihui Arlington, Massachusetts 02476 (US) LAROCQUE, Andrew Francis Arlington, Massachusetts 02476 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)