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(11)

EP 4 824 034 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24901858.1 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  C07C 229/12(2006.01) A61K 9/10(2006.01) A61K 47/18(2017.01) C12N 15/88(2006.01) A61K 9/00(2006.01) A61K 9/51(2006.01) C07C 229/16(2006.01) (52) Cooperative Patent Classification (CPC): C07C 229/12; A61K 9/5123 (86) International application number: PCT/CA2024/051647 (87) International publication number: WO 2025/123134 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 LU 505741 29.03.2024 US 202418621526 (71) Applicant: The Governing Council of the University of Toronto Toronto, Ontario M5G 1L7 (CA)	(72) Inventors: FIZAL KHAN, Omar Toronto, Ontario M5G1L7 (CA) COUTURE-SENÉCAL, Julien Toronto, Ontario M5G1L7 (CA) TILSTRA, Grayson Toronto, Ontario M5G1L7 (CA) (74) Representative: FRKelly  Waterways House Grand Canal Quay Dublin D02 PD39 Dublin D02 PD39 (IE)