(19)

(11)

EP 4 824 035 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904765.5 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  C07C 229/28(2006.01) C07F 9/12(2006.01) C12N 15/52(2006.01) C07C 229/08(2006.01) C07F 9/24(2006.01) C12N 15/63(2006.01) (52) Cooperative Patent Classification (CPC): C07F 9/28; C07F 9/65846; C12N 15/67; C12N 9/93; C12Y 601/01026 (86) International application number: PCT/US2024/059463 (87) International publication number: WO 2025/128629 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608411 P 28.12.2023 US 202363615691 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)	(72) Inventor: WANG, Lei San Francisco, CA 94158 (US) (74) Representative: HGF  HGF Limited 4th Floor, 1 City Square Leeds LS1 2ES Leeds LS1 2ES (GB)