(19)

(11)

EP 4 824 045 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24905019.6 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  C07D 239/24(2006.01) C07D 277/38(2006.01) A61P 11/00(2006.01) C07D 241/10(2006.01) A61K 31/427(2006.01) (52) Cooperative Patent Classification (CPC): A61P 11/00; C07D 513/18; C07D 515/18 (86) International application number: PCT/US2024/060181 (87) International publication number: WO 2025/129104 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363610882 P (71) Applicant: Sionna Therapeutics Inc. Waltham, Massachusetts 02451 (US)

(72) Inventors: GAO, Zhongli Waltham, Massachusetts 02451 (US) LIAO, Junkai Waltham, Massachusetts 02451 (US) TOPALOV, George Waltham, Massachusetts 02451 (US) MUNSON, Mark Waltham, Massachusetts 02451 (US) HURLBUT, Gregory Waltham, Massachusetts 02451 (US) MACOR, John E. Waltham, Massachusetts 02451 (US) (74) Representative: Heller, Benjamin Henry  Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)