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EP 4 824 047 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24841532.5 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  C07D 277/68(2006.01) C07D 451/02(2006.01) C07D 491/08(2006.01) A61P 9/00(2006.01) C07D 495/10(2006.01) A61K 31/537(2006.01) C07D 417/04(2006.01) C07D 491/048(2006.01) C07D 491/107(2006.01) C07D 495/08(2006.01) C07D 498/08(2006.01) (52) Cooperative Patent Classification (CPC): C07D 495/08; C07D 498/08; C07D 451/02; C07D 491/08; C07D 491/107; C07D 491/048; C07D 417/04; C07D 495/10; C07D 277/68; A61P 9/00 (86) International application number: PCT/US2024/059947 (87) International publication number: WO 2025/128938 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363610493 P 21.06.2024 US 202463662768 P (71) Applicant: Eli Lilly and Company Indianapolis, IN 46285 (US)

(72) Inventors: ANDERSON, Erin Indianapolis, Indiana 46206-6288 (US) FIELDS, Todd Indianapolis, Indiana 46206-6288 (US) FLYNN, Autumn Rose Indianapolis, Indiana 46206-6288 (US) MCKENNEY HALL, Megan Indianapolis, Indiana 46206-6288 (US) JOHNSTON, Richard Duane Indianapolis, Indiana 46206-6288 (US) LAMAR, Jason Eric Indianapolis, Indiana 46206-6288 (US) MAYNE, Christopher Indianapolis, Indiana 46206-6288 (US) MCFADDIN, Elizabeth Indianapolis, Indiana 46206-6288 (US) METCALF, Andrew Indianapolis, Indiana 46206-6288 (US) SAMMAKIA, Tarek Indianapolis, Indiana 46206-6288 (US) SUN, Zhicheng Indianapolis, Indiana 46206-6288 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)