(19)

(11)

EP 4 824 049 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24847295.3 (22) Date of filing: 16.12.2024

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) C07D 405/14(2006.01) C07D 471/04(2006.01) A61K 31/4439(2006.01) C07D 401/14(2006.01) C07D 413/14(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/14; C07D 401/04; C07D 405/14; C07D 413/14; C07D 471/04; A61P 35/00 (86) International application number: PCT/US2024/060337 (87) International publication number: WO 2025/129168 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363610682 P (71) Applicants: The United States of America, as represented by The Secretary, Department of Health and Human Services Bethesda, Maryland 20982-7788 (US) University of Chicago Chicago, IL 60673 (US) Schrödinger, Inc. New York, NY 10036 (US) Curia Global, Inc. Albany, NY 12203 (US)

(72) Inventors: PATNAIK, Samarjit Bethesda, Maryland 20892-7788 (US) SHRIMP, Jonathan Harold Bethesda, Maryland 20892-7788 (US) SUN, Hongmao Bethesda, Maryland 20892-7788 (US) MARUGAN, Juan Jose Bethesda, Maryland 20892-7788 (US) KONG, Ke Bethesda, Maryland 20892-7788 (US) LIU, Li Bethesda, Maryland 20892-7788 (US) HALL, Matthew D. Bethesda, Maryland 20892-7788 (US) FLINT, Andrew John Frederick, Maryland 21701 (US) SHEN, Min Bethesda, Maryland 20892-7788 (US) HANSON, Quinlin M. Bethesda, Maryland 20892-7788 (US) CHENG, Chih-Chien Bethesda, Maryland 20892-7788 (US) YANG, Tae Gyun Bethesda, Maryland 20892-7788 (US) MOORE, William Jay Frederick, Maryland 21702 (US) HEIDE, Janna Chicago, Illinois 60615 (US) LENGYEL, Ernst Chicago, Illinois 60637 (US) JANISZEWSKI, John Stephen Bethesda, Maryland 20892-7788 (US) STOTT, Gordon Frederick, MD 21702 (US) GREEN, Neal Frederick, MD 21702 (US) ECKERT, Mark Chicago, IL 60637 (US) ALLEGA, Maria Francesca Chicago, IL 60637 (US) WHITE, Andre New York, 10036 (US) WOLF, Mark Allan Williamsville, 14221 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)