(19)
(11) EP 4 824 052 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24866570.5

(22) Date of filing: 12.12.2024
(51) International Patent Classification (IPC): 
C07D 401/14(2006.01)
A61K 31/44(2006.01)
A61P 35/00(2006.01)
 C07D 487/04(2006.01)
A61K 31/5025(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 487/04; C07D 401/14; A61P 35/00
(86) International application number:
PCT/IB2024/062590
(87) International publication number:
WO 2025/126115 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 13.12.2023 WO PCT/CN2023/138418

(71) Applicant: Beone Medicines I GmbH
4051 Basel (CH)

(72) Inventors:
  • SUN, Dongqing
    Beijing 102206 (CN)
  • LIU, Huaqing
    Beijing 102206 (CN)
  • WANG, Zhiwei
    Beijing 102206 (CN)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)

   


(54) DEGRADATION OF IRAK4 BY CONJUGATION OF IRAK4 INHIBITORS WITH E3 LIGASE LIGANDS AND METHODS OF USE