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EP 4 824 059 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24840865.0 (22) Date of filing: 16.12.2024

(51) International Patent Classification (IPC):  C07D 413/06(2006.01) C07D 417/14(2006.01) A61P 31/04(2006.01) A61K 31/428(2006.01) C07D 417/06(2006.01) C07D 487/04(2006.01) A61K 31/423(2006.01) A61K 31/519(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/04; C07D 417/14; C07D 487/04; C07D 417/06; C07D 413/06 (86) International application number: PCT/GB2024/053125 (87) International publication number: WO 2025/125829 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 GB 202319181 (71) Applicant: Imperial College Innovations Limited London SW7 2AZ (GB)	(72) Inventors: GRAY, Janine L. London Greater London SW7 2AZ (GB) LEDGER, Elizabeth V.K. London Greater London SW7 2AZ (GB) BURDEN, Thomas London Greater London SW7 2AE (GB) EDWARDS, Andrew London Greater London SW7 2AE (GB) TATE, Edward W. London Greater London SW7 2AZ (GB) (74) Representative: Crow, Martin  Venner Shipley LLP TIDE Bankside 8 Emerson Street London SE1 9DU London SE1 9DU (GB)