(19)

(11)

EP 4 824 060 A2

(12)

(88) Date of publication A3: 04.09.2025 (43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24834315.4 (22) Date of filing: 16.12.2024

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61P 35/00(2006.01) C07D 519/00(2006.01) C07D 401/12(2006.01) C07D 471/10(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/12; C07D 471/10; C07D 519/00; A61P 35/00; C07D 401/14; C07D 471/04 (86) International application number: PCT/EP2024/086638 (87) International publication number: WO 2025/125688 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 GB 202319256 (71) Applicant: Amphista Therapeutics Ltd Great Abington, Cambridge CB21 6GQ (GB)	(72) Inventors: BROWN, Giles Albert Cambridge CB21 6GQ (GB) MCGARRY, David Cambridge CB21 6GQ (GB) DROUHIN, Pauline Cambridge CB21 6GQ (GB) TIBERGHIEN, Nathalie Cambridge CB21 6GQ (GB) AMBLER, Martin Cambridge CB21 6GQ (GB) HAMBY, Callum Cambridge CB21 6GQ (GB) (74) Representative: Elkington and Fife LLP  Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)