(19)
(11) EP 4 824 062 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24904934.7

(22) Date of filing: 13.12.2024
(51) International Patent Classification (IPC): 
C07D 471/06(2006.01)
A61K 31/407(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 471/04; C07D 491/147; A61P 25/00; A61K 31/437
(86) International application number:
PCT/US2024/059939
(87) International publication number:
WO 2025/128933 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 14.12.2023 US 202363610292 P

(71) Applicant: The Brigham & Women's Hospital, Inc.
Boston, Massachusetts 02115 (US)

(72) Inventors:
  • HODGETTS, Kevin Julian
    Framingham, Massachusetts 01701 (US)
  • DOLLER, Dario
    Sparta, New Jersey 07871 (US)

(74) Representative: Purdylucey Intellectual Property 
23 Ely Place
Dublin 2 D02 N285
Dublin 2 D02 N285 (IE)

   


(54) GABA-A RECEPTOR POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF