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EP 4 824 066 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24837496.9 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61P 19/02(2006.01) A61P 25/14(2006.01) A61P 37/06(2006.01) C07D 471/04(2006.01) A61P 19/06(2006.01) A61P 25/28(2006.01) A61K 31/437(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; C07D 487/04; A61K 31/437; A61P 19/02; A61P 25/14; A61P 25/28; A61P 37/06; A61P 19/06 (86) International application number: PCT/US2024/059705 (87) International publication number: WO 2025/128781 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610235 P (71) Applicant: Merck Sharp & Dohme LLC Rahway, New Jersey 07065 (US)

(72) Inventors: BRILL, Zachary G. Rahway, New Jersey 07065 (US) HAYES, Donna A. A. W. Rahway, New Jersey 07065 (US) LAM, Tom M. Rahway, New Jersey 07065 (US) MCCLYMONT, Kyle S. Rahway, New Jersey 07065 (US) MATSUURA, Bryan S. Rahway, New Jersey 07065 (US) MERCHANT, Rohan Rajiv Rahway, New Jersey 07065 (US) NAIR, Anilkumar G. Rahway, New Jersey 07065 (US) QI, Ning Rahway, New Jersey 07065 (US) (74) Representative: Merck Sharp & Dohme LLC  120 Moorgate London EC2M 6UR London EC2M 6UR (GB)