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EP 4 824 069 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24821066.8 (22) Date of filing: 09.12.2024

(51) International Patent Classification (IPC):  C07D 491/20(2006.01) C07D 471/20(2006.01) A61P 27/02(2006.01) A61K 31/438(2006.01) C07D 471/10(2006.01) A61P 25/28(2006.01) A61P 29/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 491/20; C07D 471/10; C07D 471/20; A61P 27/02; A61P 29/00; A61P 25/28 (86) International application number: PCT/EP2024/085228 (87) International publication number: WO 2025/125135 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 EP 23215459 (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)

(72) Inventors: ANTOINE, Mathias 4070 Basel (CH) BARTELS, Bjoern 4070 Basel (CH) DEY, Fabian 4070 Basel (CH) EDMONDS, David James 4070 Basel (CH) HUNZIKER, Daniel 4070 Basel (CH) KORN, Claudia Irina 4070 Basel (CH) RAGELLE, Héloïse Alexandra 4070 Basel (CH) STEINBRECHER, Thomas Bernd 4070 Basel (CH) URNER, Lorenz Michael 4070 Basel (CH) VEGA-CES, Sabela 4070 Basel (CH) (74) Representative: Neuhaus, Christian Michel  F. Hoffmann-La Roche AG Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)