(19)

(11)

EP 4 824 073 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904796.0 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  C07F 5/02(2006.01) A61K 47/18(2017.01) A61K 38/00(2006.01) C07K 7/06(2006.01) A61K 47/42(2017.01) (52) Cooperative Patent Classification (CPC): A61K 38/00; C07K 7/06; A61K 38/26; A61P 3/10; A61K 9/5031; A61K 9/5146; A61K 9/0019; C07F 5/025 (86) International application number: PCT/US2024/059543 (87) International publication number: WO 2025/128687 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608410 P (71) Applicant: University of Notre Dame du Lac South Bend, Indiana 46617 (US)	(72) Inventors: WEBBER, Matthew J. South Bend, Indiana 46617 (US) YU, Sihan South Bend, Indiana 46617 (US) CHEN, Weike South Bend, Indiana 46617 (US) KADU, Pradeep South Bend, Indiana 46617 (US) (74) Representative: Marks & Clerk LLP  15 Fetter Lane London EC4A 1BW London EC4A 1BW (GB)