(19)
(11) EP 4 824 078 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24834179.4

(22) Date of filing: 12.12.2024
(51) International Patent Classification (IPC): 
C07K 7/08(2006.01)
A61K 38/00(2006.01)
 C07K 7/64(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 7/64; C07K 7/08; A61K 38/00
(86) International application number:
PCT/US2024/059742
(87) International publication number:
WO 2025/128805 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 15.12.2023 US 202363610766 P
17.07.2024 US 202463672292 P

(71) Applicant: Merck Sharp & Dohme LLC
Rahway, New Jersey 07065 (US)

(72) Inventors:
  • CRUZ, Faben A.
    Rahway, New Jersey 07065 (US)
  • HANISAK, Jennifer
    Rahway, New Jersey 07065 (US)
  • HICKEY, Jennifer L.
    Rahway, New Jersey 07065 (US)
  • KEKEC, Ahmet
    Rahway, New Jersey 07065 (US)
  • KEREKES, Angela D.
    Marlborough, Massachusetts 01752 (US)
  • PISSARNITSKI, Dmitri A.
    Rahway, New Jersey 07065 (US)
  • PLUMMER, Christopher W.
    Rahway, New Jersey 07065 (US)
  • ABATE, Luigi
    00071 Pomezia (RM) (IT)
  • BIANCHI, Elisabetta
    00071 Pomezia (RM) (IT)
  • COLARUSSO, Stefania
    00071 Pomezia (RM) (IT)
  • MANDIC, Emanuela
    00071 Pomezia (RM) (IT)
  • PAVONE, Francesca
    00071 Pomezia (RM) (IT)
  • YOUSIF, Ali Munaim
    00071 Pomezia (RM) (IT)

(74) Representative: Merck Sharp & Dohme LLC 
120 Moorgate
London EC2M 6UR
London EC2M 6UR (GB)

   


(54) A CYCLIC PEPTIDE IL-1BETA TRAP FOR THE TREATMENT OF ATHEROSCLEROSIS AND INFLAMMATORY DISORDERS