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EP 4 824 086 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24829096.7 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  C07K 16/10(2026.01) A61P 31/16(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): A61K 2039/505; A61K 2039/507; A61P 31/16; C07K 2317/22; C07K 2317/24; C07K 2317/31; C07K 2317/33; C07K 2317/34; C07K 2317/52; C07K 2317/569; C07K 2317/62; C07K 2317/64; C07K 2317/732; C07K 2317/76; C07K 2319/00; C07K 16/108 (86) International application number: PCT/EP2024/086236 (87) International publication number: WO 2025/125577 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 EP 23216759 12.09.2024 EP 24199972 (71) Applicants: VIB VZW 9052 Gent (BE) Universiteit Gent 9000 Gent (BE)	(72) Inventors: SAELENS, Xavier 9052 Gent (BE) MATTHYS, Arne 9052 Gent (BE) SAVVIDES, Savvas 9052 Gent (BE) FELIX, Jan 9052 Gent (BE)