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(11)

EP 4 824 094 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24829102.3 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 40/31(2025.01) A61P 35/00(2006.01) A61K 40/15(2025.01) A61K 40/42(2025.01) (52) Cooperative Patent Classification (CPC): A61K 2239/13; A61K 2239/17; A61K 2239/21; A61K 2239/22; A61K 2239/48; A61P 35/00; A61K 40/15; A61K 40/4219; A61K 40/31; C07K 16/2866; C07K 2317/622 (86) International application number: PCT/EP2024/086312 (87) International publication number: WO 2025/125610 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 EP 23217219 (71) Applicant: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft 13125 Berlin (DE)	(72) Inventors: HÖPKEN, Uta Elisabeth 14057 Berlin (DE) REHM, Armin 14057 Berlin (DE) MASSARO, Marialucia 10409 Berlin (DE) BUNSE, Mario 10961 Berlin (DE) (74) Representative: Hertin und Partner Rechts- und Patentanwälte PartG mbB  Kurfürstendamm 63 10707 Berlin 10707 Berlin (DE)