(19)
(11) EP 4 824 099 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24904681.4

(22) Date of filing: 09.12.2024
(51) International Patent Classification (IPC): 
C07K 16/28(2006.01)
B01D 15/20(2006.01)
B01D 15/36(2006.01)
B01D 15/42(2006.01)
 B01D 15/16(2006.01)
B01D 15/32(2006.01)
B01D 15/38(2006.01)
C07K 1/22(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 16/2818; C07K 2317/24; C07K 2317/94; B01D 15/3847
 
C-Sets:
B01D 15/363, B01D 15/327;
(86) International application number:
PCT/US2024/059143
(87) International publication number:
WO 2025/128465 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 12.12.2023 US 202363609155 P

(71) Applicant: Merck Sharp & Dohme LLC
Rahway, New Jersey 07065 (US)

(72) Inventors:
  • BROWER, Mark A.
    Rahway, New Jersey 07065 (US)
  • DOS SANTOS PINTO, Nuno Jorge
    Rahway, New Jersey 07065 (US)
  • RAYFIELD, William J.
    Rahway, New Jersey 07065 (US)
  • ROBINSON, Julie R.
    Rahway, New Jersey 07065 (US)

(74) Representative: Merck Sharp & Dohme LLC 
120 Moorgate
London EC2M 6UR
London EC2M 6UR (GB)

   


(54) METHODS OF PURIFYING ANTI-PD-1 ANTIBODIES OR ANTIGEN-BINDING FRAGMENTS THEREOF USING MIXED-MODE ANION-EXCHANGE CHROMATOGRAPHY