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EP 4 824 100 A2

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(88) Date of publication A3: 14.08.2025 (43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904826.5 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) A61K 47/68(2017.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/6849; A61K 47/6851; A61K 47/68031; A61K 47/6889; A61P 35/00 (86) International application number: PCT/US2024/059633 (87) International publication number: WO 2025/128735 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608714 P (71) Applicants: Nextcure, Inc. Beltsville, MD 20705 (US) LigaChem Biosciences, Inc. Daejeon (KR)

(72) Inventors: FITZGERALD, Daniel P. Beltsville, Maryland 20705 (US) FLIES, Dallas Benjamin Beltsville, Maryland 20705 (US) LANGERMANN, Solomon Beltsville, Maryland 20705 (US) JUNG, Kwang Hwa Daejeon (KR) OH, Hwanhee Daejeon (KR) CHUNG, Chul-Woong Daejeon (KR) SONG, Ho Young Daejeon (KR) KANG, Myungji Daejeon (KR) (74) Representative: D Young & Co LLP  3 Noble Street London EC2V 7BQ London EC2V 7BQ (GB)