(19)

(11)

EP 4 824 101 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904877.8 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 39/395(2006.01) C12N 15/79(2006.01) C07K 16/46(2006.01) A01K 67/0278(2024.01) A61P 25/28(2006.01) C12N 5/10(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/28; C12N 15/79; C07K 16/2803; C07K 2317/31; C07K 2317/76; C07K 2317/75; A61K 2039/505; A61K 2039/507; A01K 67/0275; A01K 2217/052; A01K 2227/105; A01K 2217/15; A01K 2267/0312; A01K 2207/15 (86) International application number: PCT/US2024/059782 (87) International publication number: WO 2025/128830 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 12.12.2023 US 202363608965 P (71) Applicant: The Methodist Hospital Houston, Texas 77030 (US)	(72) Inventors: CHEN, Shu-Hsia Houston, Texas 77030 (US) PAN, Ping-Ying Houston, Texas 77030 (US) DAVIDOV, Vitaliy Houston, Texas 77004 (US) (74) Representative: The IP Asset Partnership Limited  Prama House 267 Banbury Road Oxford OX2 7HT Oxford OX2 7HT (GB)