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EP 4 824 102 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904884.4 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 39/395(2006.01) C40B 40/02(2006.01) C12P 21/00(2006.01) C12N 15/79(2006.01) A61P 25/00(2006.01) C12N 5/10(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/00; C07K 16/28; C07K 2317/75; C07K 2317/22; C07K 2317/569; C07K 2317/33; A61K 2039/505; C07K 2317/70; C07K 2317/94; C07K 2317/92; C07K 2317/565; C12N 15/70; C12N 5/0688; C12N 5/0645; C12N 2500/72; C12N 2510/00 (86) International application number: PCT/US2024/059810 (87) International publication number: WO 2025/128847 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609666 P 04.03.2024 US 202463561029 P 10.05.2024 US 202463645515 P 02.08.2024 US 202463679061 P 05.11.2024 US 202463716676 P (71) Applicant: Abalone Bio, Inc. Emeryville, CA 94608 (US)

(72) Inventors: BALTANÁS, Rodrigo Emeryville, California 94608 (US) ROBISON, Brett Emeryville, California 94608 (US) YU, Richard Emeryville, California 94608 (US) PESCE, Carlos Gustavo deceased (US) COOKE, Allison Emeryville, California 94608 (US) TAKEUCHI, Toshihiko Emeryville, California 94608 (US) HASSANZADEH-GHASSABEH, Gholamreza Emeryville, California 94608 (US) SCHWIMMER, Lauren Emeryville, California 94608 (US) SCHWARTZ, Monica Emeryville, California 94608 (US) SOI, Sameer Emeryville, California 94608 (US) LIU, Jingjing Emeryville, California 94608 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)