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(11)

EP 4 824 104 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24905004.8 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) G01N 33/68(2006.01) C07K 14/705(2006.01) A61P 13/12(2006.01) A61K 39/395(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61K 2039/507; A61K 2039/505; C07K 2317/76; A61K 2039/545; C07K 16/2839; C07K 2317/92; C07K 2317/24; C07K 16/2818; C07K 2317/90; C07K 2317/94; C07K 16/2827; A61K 39/39591 (86) International application number: PCT/US2024/060133 (87) International publication number: WO 2025/129072 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609748 P (71) Applicant: Corbus Pharmaceuticals, Inc. Norwood, MA 02062 (US)	(72) Inventors: KOLODZIEJ, Andrew Winchester, MA 01890 (US) HAINES, Eric Andover, MA 01810 (US) MORSE, Richard, J. Bethel, CT 06801 (US) BHATTACHARYA, Tuhina Brockton, MA 02301 (US) SLAMAN, Paul Plainville, MA 02762 (US) (74) Representative: Kransell & Wennborg KB  P.O. Box 27834 115 93 Stockholm 115 93 Stockholm (SE)