(19)

(11)

EP 4 824 106 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24905061.8 (22) Date of filing: 16.12.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) A61K 47/68(2017.01) A61P 1/16(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61P 1/16; C07K 2317/76; C07K 2317/34; C07K 2317/92; C07K 16/2803 (86) International application number: PCT/US2024/060297 (87) International publication number: WO 2025/129160 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610259 P (71) Applicant: The Research Foundation for The State University of New York Amherst, NY 14228 (US)	(72) Inventors: XU, Ding Amherst, New York 14051 (US) ONG, Chih Yean Buffalo, New York 14226 (US) LI, Miaomiao Tonawanda, New York 14150 (US) (74) Representative: Brantsandpatents bv  Pauline Van Pottelsberghelaan 24 9051 Ghent 9051 Ghent (BE)