(19)

(11)

EP 4 824 147 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24905032.9 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  C08G 65/334(2006.01) A61P 31/20(2006.01) A61K 39/39(2006.01) A61P 35/04(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/20; A61P 35/04; C08G 65/334; A61K 39/0011; A61K 2039/6031; A61K 2039/55572; A61K 2039/55516; A61K 2039/572; A61K 2039/86; A61K 2039/55555; A61K 39/12; C12N 2710/16034; A61K 9/0019; A61K 9/5123 (86) International application number: PCT/US2024/060211 (87) International publication number: WO 2025/129124 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363610642 P (71) Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM Austin, TX 78701 (US)	(72) Inventors: GAO, Jinming Dallas, Texas 75390 (US) HUANG, Gang Dallas, Texas 75390 (US) CHEN, Shuang Dallas, Texas 75390 (US) YE, Shuyue Dallas, Texas 75390 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)