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EP 4 824 229 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24911593.2 (22) Date of filing: 29.12.2024

(51) International Patent Classification (IPC):  C12N 1/21(2006.01) A61P 31/04(2006.01) A61K 35/74(2015.01) C12R 1/445(2006.01) (52) Cooperative Patent Classification (CPC): A61K 39/085; A61P 15/14; A61P 17/00; A61P 19/02; A61P 31/04; C12N 1/20; A61K 2039/552; A61K 2039/55505; C07K 14/31; C12R 2001/445 (86) International application number: PCT/CN2024/143562 (87) International publication number: WO 2025/140679 (03.07.2025 Gazette 2025/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.12.2023 WO PCT/CN2023/143345 (71) Applicant: Shanghai Yuguan Biotech Co., Ltd. Shanghai 200120 (CN)	(72) Inventors: ZHANG, Mengya Shanghai 200120 (CN) LIN, Qiubin Shanghai 200120 (CN) LEE, Ming-Chun Shanghai 200120 (CN) WANG, Mingrui Shanghai 200120 (CN) (74) Representative: IK-IP LTD  8 Devonshire Square London EC2M 4YJ London EC2M 4YJ (GB)