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EP 4 824 244 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24837780.6 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  C12N 9/18(2006.01) C12N 15/52(2006.01) C08J 11/10(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/18; C12Y 301/01; C12N 15/52; C08J 11/105 (86) International application number: PCT/US2024/059940 (87) International publication number: WO 2025/128934 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 15.12.2023 US 202363610541 P 15.12.2023 US 202363610546 P (71) Applicant: Flagship Pioneering Innovations VII, LLC Cambridge, MA 02142 (US)

(72) Inventors: TIAN, Pengfei Cambridge, Massachusetts 02142 (US) SORENSEN, Trine Holst Cambridge, Massachusetts 02142 (US) JONES, Stephen Merritt Cambridge, Massachusetts 02142 (US) GIBSON, Molly Krisann Cambridge, Massachusetts 02142 (US) SNEIDER, Alexandra Rachael Cambridge, Massachusetts 02142 (US) BOGHIGIAN, Brett Adam Cambridge, Massachusetts 02142 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)