(19)
(11) EP 4 824 251 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24834176.0

(22) Date of filing: 11.12.2024
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
 A61K 31/713(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/113; C12N 2310/14; A61K 31/713; C12N 2320/35; C12N 2310/3183
 
C-Sets:
  1. C12N 2310/321, C12N 2310/3521;
  2. C12N 2310/322, C12N 2310/3533;
  3. C12N 2310/315, C12N 2310/344;
(86) International application number:
PCT/US2024/059444
(87) International publication number:
WO 2025/128614 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 12.12.2023 US 202363608909 P

(71) Applicant: Alnylam Pharmaceuticals, Inc.
Cambridge, MA 02142 (US)

(72) Inventors:
  • BHAN, Ishir
    Cambridge, MA 02142 (US)
  • ZAPPE, Dion
    Cambridge, MA 02142 (US)
  • GUO, Weinong
    Cambridge, MA 02142 (US)
  • MEHROTRA, Nitin
    Cambridge, MA 02142 (US)
  • KHURANA, Manoj
    Cambridge, MA 02142 (US)
  • LEE, Jongtae
    Cambridge, MA 02142 (US)
  • LASKO, Maxwell
    Cambridge, MA 02142 (US)
  • PARK, Wansu
    Cambridge, MA 02142 (US)
  • YUN, Hyun, Gi
    Cambridge, MA 02142 (US)
  • ROBBIE, Gabriel
    Cambridge, MA 02142 (US)

(74) Representative: Potter Clarkson 
Chapel Quarter Mount Street
Nottingham NG1 6HQ
Nottingham NG1 6HQ (GB)

   


(54) METHODS AND COMPOSITIONS FOR TREATING AN ANGIOTENSINOGEN- (AGT-) ASSOCIATED DISORDER