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(11)

EP 4 824 252 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24834947.4 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/713(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; C12N 2310/321; C12N 2310/322; C12N 2310/14; C12N 2310/315; C12N 2310/3515; C12N 15/1137; A61K 31/713; A61K 45/06   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/322, C12N 2310/3533; (86) International application number: PCT/US2024/059469 (87) International publication number: WO 2025/128632 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 12.12.2023 US 202363608906 P 12.06.2024 US 202463659007 P (71) Applicant: Alnylam Pharmaceuticals, Inc. Cambridge, MA 02142 (US)	(72) Inventors: MARATOS-FLIER, Eleftheria Cambridge, MA 02142 (US) NANDI, Tirtha Cambridge, MA 02142 (US) GAO, Xiuqing Cambridge, MA 02142 (US) JADHAV, Satyawan Cambridge, MA 02142 (US) KHURANA, Manoj Cambridge, MA 02142 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)