(19)

(11)

EP 4 824 256 A2

(12)

(88) Date of publication A3: 21.08.2025 (43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24863813.2 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 40/31(2025.01) C12N 9/78(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/1137; C12N 2310/20; C12N 15/113; C12N 15/1138; A61K 40/11; A61K 40/31; C12N 9/78; C12Y 305/04001; C12N 9/16; C12Y 301/00; C12N 2320/31; C07K 14/7051; C12N 2750/14143; A61K 2239/31; A61K 2239/38; A61K 2239/10; A61P 35/00; A61K 2239/56; A61K 40/4232; A61K 40/4215; A61K 40/50 (86) International application number: PCT/IB2024/062469 (87) International publication number: WO 2025/126049 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 11.12.2023 US 202363608807 P (71) Applicant: CRISPR Therapeutics AG 6300 Zug (CH)

(72) Inventors: KULMAN, John South Boston, Massachusetts 02127 (US) FERULLO, Daniel South Boston, Massachusetts 02127 (US) FOCHTMAN, Brian South Boston, Massachusetts 02127 (US) VISHWANATHAN, Aishwarya South Boston, Massachusetts 02127 (US) ACHUTHAN, Vasudevan South Boston, Massachusetts 02127 (US) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstraße 3 81675 München 81675 München (DE)