(19)
(11) EP 4 824 258 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24902785.5

(22) Date of filing: 10.12.2024
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
A61P 3/06(2006.01)
A61P 35/04(2006.01)
 A61K 31/713(2006.01)
A61P 35/00(2006.01)
A61P 9/00(2006.01)
(52) Cooperative Patent Classification (CPC):
C12Y 304/21061; C12N 2310/14; C12N 2310/315; C12N 2310/321; C12N 2310/322; C12N 2310/332; C12N 2310/351; C12N 15/1137; A61K 31/713
 
C-Sets:
  1. C12N 2310/321, C12N 2310/3521;
  2. C12N 2310/322, C12N 2310/3533;
(86) International application number:
PCT/CN2024/137988
(87) International publication number:
WO 2025/124364 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 11.12.2023 CN 202311686000

(71) Applicant: Hangzhou Dinovate Biotech Co., Ltd.
Zhejiang 310051 (CN)

(72) Inventors:
  • ZHANG, Rui
    Shanghai 200021 (CN)
  • WANG, Dongdong
    Shanghai 200021 (CN)
  • LIU, Xinxing
    Shanghai 200021 (CN)
  • ZHOU, Rui
    Shanghai 200131 (CN)
  • TAN, Qingqiao
    Shanghai 200131 (CN)

(74) Representative: Straus, Alexander 
2K Patentanwälte - München Bajuwarenring 14
82041 Oberhaching
82041 Oberhaching (DE)

   


(54) SIRNA MOLECULE FOR INHIBITING PCSK9 EXPRESSION AND USE THEREOF