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EP 4 824 259 A1

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(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904740.8 (22) Date of filing: 10.12.2024

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/712(2006.01) A61K 31/713(2006.01) A61P 29/00(2006.01) C12N 15/85(2006.01) A61K 31/7125(2006.01) A61K 47/68(2017.01) (52) Cooperative Patent Classification (CPC): C12N 2310/335; C12N 15/1138; C12N 2310/14; C12N 2310/315; C12N 2310/321; C12N 2310/3521; C12N 2310/322; C12N 2310/3533; C07K 16/2881; A61K 2039/505; A61K 47/6849; A61K 47/6807 (86) International application number: PCT/US2024/059406 (87) International publication number: WO 2025/128589 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609643 P (71) Applicants: Eli Lilly and Company Indianapolis, IN 46285 (US) Atrium Therapeutics, Inc. San Diego, CA 92121 (US)

(72) Inventors: BOYLES, Jeffrey Indianapolis, IN 46206-6288 (US) BHATTACHARYA, Arvind San Diego, CA 92121 (US) BROWN-AUGSBURGER, Patricia Indianapolis, IN 46206-6288 (US) COCHRAN, Michael Caramian San Diego, CA 92121 (US) DAVIES, Julian Indianapolis, IN 46206-6288 (US) HOBBS, Wendy Loza Indianapolis, IN 46206-6288 (US) KWAN, Yu Yan San Diego, CA 92121 (US) MATALONGA BORREL, Jonatan San Diego, CA 92121 (US) MCDERMOTT, Jeff S. Indianapolis, IN 46206-6288 (US) OLIVA DETANICO, Thiago San Diego, CA 92121 (US) WALL, Christopher Earle San Diego, CA 92121 (US) (74) Representative: Eli Lilly and Company Limited  8 Arlington Square West Downshire Way Bracknell, Berkshire RG12 1PU Bracknell, Berkshire RG12 1PU (GB)