(19)

(11)

EP 4 824 261 A2

(12)

(88) Date of publication A3: 21.08.2025 (43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904883.6 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/712(2006.01) A61K 31/7115(2006.01) A61K 31/7125(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; C12N 2310/315; C12N 2310/322; C12N 2310/11; C12N 2310/341; C12N 2310/346   C-Sets: C12N 2310/322, C12N 2310/3525; (86) International application number: PCT/US2024/059808 (87) International publication number: WO 2025/128846 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609644 P (71) Applicant: Pretzel Therapeutics, Inc. Waltham, MA 02451 (US)	(72) Inventors: XIE, Xie Waltham, Massachusetts 02451 (US) SHI, Yonghong Waltham, Massachusetts 02451 (US) ZHU, Xuefeng Waltham, Massachusetts 02451 (US) (74) Representative: Coles, Andrea Birgit et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)