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(11)

EP 4 824 262 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24904914.9 (22) Date of filing: 12.12.2024

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/7115(2006.01) A61K 38/17(2006.01) C12P 19/34(2006.01) A61K 48/00(2006.01) C12N 15/85(2006.01) A61K 9/127(2025.01) A61K 31/712(2006.01) C12N 9/12(2006.01) C12N 15/11(2006.01) C07K 14/705(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/7115; A61K 31/712; C12N 15/11; C12N 15/85; C12P 19/34; C12N 2840/203; C07K 14/7051; C07K 2319/03; C12Y 605/01003; C12N 9/1247; A61K 38/00; C12N 2310/532 (86) International application number: PCT/US2024/059894 (87) International publication number: WO 2025/128901 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610356 P (71) Applicant: Arcturus Therapeutics, Inc. San Diego, CA 92121 (US)	(72) Inventors: CHIVUKULA, Padmanabh San Diego, CA 92121 (US) TACHIKAWA, Kiyoshi San Diego, CA 92121 (US) IM, Yunki San Diego, CA 92121 (US) HILL, Brett San Diego, CA 92121 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)