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(11)

EP 4 824 266 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24905007.1 (22) Date of filing: 13.12.2024

(51) International Patent Classification (IPC):  C12N 15/63(2006.01) C12N 5/077(2010.01) C12N 15/85(2006.01) A61K 48/00(2006.01) C12N 5/00(2006.01) A61K 35/34(2015.01) C12N 15/86(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/63; C12N 15/86; C12N 2830/008; C12N 2830/60; C12N 2830/15; C12N 2750/14143; A61K 48/005; A61K 48/0058 (86) International application number: PCT/US2024/060141 (87) International publication number: WO 2025/129079 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 13.12.2023 US 202363609724 P (71) Applicant: Tenaya Therapeutics, Inc. South San Francisco, Ca 94080 (US)	(72) Inventors: KONKALMATT, Prasad R. South San Francisco, California 94080 (US) MANDEGAR, Mohammad Ali South San Francisco, California 94080 (US) REID, Christopher A. South San Francisco, California 94080 (US) (74) Representative: Goodwin Procter (UK) LLP  Sancroft, 10-15 Newgate Street EC1A 7AZ / London EC1A 7AZ / London (GB)