(19)

(11)

EP 4 824 267 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24834449.1 (22) Date of filing: 11.12.2024

(51) International Patent Classification (IPC):  C12N 15/67(2006.01) A61K 39/12(2006.01) C07K 14/005(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/67; C12N 2760/18534; C12N 2760/18522; A61K 39/12; C07K 14/005; A61K 2039/53; A61K 2039/572; A61K 2039/575; A61K 2039/55555; A61P 31/14 (86) International application number: PCT/IB2024/062510 (87) International publication number: WO 2025/126071 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610042 P 14.02.2024 US 202463553480 P 14.03.2024 US 202463565428 P 20.03.2024 US 202463567866 P 26.04.2024 US 202463639366 P 26.11.2024 US 202463725096 P (71) Applicant: Pfizer Inc. New York, NY 10001-2192 (US)

(72) Inventors: BENNETT, Eric Matthew Cambridge, Massachusetts 02139 (US) HEWA DEWAGE, Amendra Fernando Cambridge, Massachusetts 02139 (US) LIN LOHSE, Laura Cambridge, Massachusetts 02139 (US) MADDUR SATHYANARAYANA, Mohan Frederick, Maryland 21704 (US) SWANSON, Kena Anne Pearl River, New York 10965 (US) (74) Representative: Pfizer  European Patent Department 23-25 avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)