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(11)

EP 4 824 270 A1

(12)

(43) Date of publication: 21.10.2026 Bulletin 2026/43 (21) Application number: 24905056.8 (22) Date of filing: 14.12.2024

(51) International Patent Classification (IPC):  C12N 15/82(2006.01) A01P 3/00(2006.01) C12N 15/113(2010.01) C12N 1/00(2006.01) (52) Cooperative Patent Classification (CPC): A01P 3/00; C12N 1/00; C12N 1/14; C12N 1/20; C12Y 301/02; C12N 15/113; A61K 9/5068; A01N 63/60; C12N 2310/14 (86) International application number: PCT/US2024/060257 (87) International publication number: WO 2025/129153 (19.06.2025 Gazette 2025/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 14.12.2023 US 202363610326 P 11.04.2024 US 202463632811 P (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: JIN, Hailing Riverside, CA 92521 (US) CHEN, Angela Riverside, CA 92521 (US) NINO SANCHEZ, Jonatan Riverside, CA 92521 (US) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstraße 3 81675 München 81675 München (DE)