(19)
(11) EP 4 824 273 A1

(12)

(43) Date of publication:
21.10.2026 Bulletin 2026/43

(21) Application number: 24828045.5

(22) Date of filing: 12.12.2024
(51) International Patent Classification (IPC): 
C12P 19/34(2006.01)
C12Q 1/68(2018.01)
(52) Cooperative Patent Classification (CPC):
C12P 19/34
(86) International application number:
PCT/EP2024/085815
(87) International publication number:
WO 2025/125387 (19.06.2025 Gazette 2025/25)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 15.12.2023 EP 23217003

(71) Applicant: F. Hoffmann-La Roche SA
4070 Basel (CH)

(72) Inventors:
  • FALIVENE, Fabio
    4070 Basel (CH)
  • MUELLER, Pascal
    4070 Basel (CH)
  • OLBRICH, Martin
    4070 Basel (CH)
  • STRUB, Daniel
    4070 Basel (CH)
  • ZEENDER, Johanna
    4070 Basel (CH)

(74) Representative: Salud, Carlos E. 
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel
4070 Basel (CH)

   


(54) PROCESS FOR THE ANNEALING OF DOUBLE STRANDED OLIGONUCLEOTIDES USING CROSSFLOW FILTRATION TECHNOLOGY